IgA pemphigus associated with monoclonal gammopathy completely resolved after achievement of complete remission of multiple myeloma with bortezomib, cyclophosphamide and dexamethasone regimen

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Authors

ADAM Zdeněk KREJČÍ Marta POUR Luděk FEIT Josef BÜCHLER Tomáš HÁJEK Roman

Year of publication 2010
Type Article in Periodical
Magazine / Source Wiener klinische Wochenschrift
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords IgA pemphigus;bortezomib; rituximab; monoclonal gammopathy
Description Monoclonal gammopathy-associated IgA pemphigus is a debilitating skin disorder with inconsistent response to treatment. A 61-year-old woman with IgA pemphigus and monoclonal gammopathy of unknown significance had been treated with bortezomib, cyclophosphamide and dexamethasone regimen, which resulted in complete and durable remission of multiple myeloma and IgA pemphigus. This suggests that bortezomib-based therapy is useful for the treatment of the rare dermatologic disorder associated with IgA gammopathy.
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