Cytotoxic Activities of Several Geranyl-Substituted Flavanones

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Authors	ŠMEJKAL Karel SVAČINOVÁ Jana ŠLAPETOVÁ Tereza SCHNEIDEROVÁ Kristýna DALL'ACQUA Stefano INNOCENTI Gabbriela ZÁVALOVÁ Veronika KOLLÁR Peter CHUDÍK Stanislav MAREK Radek JULÍNEK Ondřej URBANOVÁ Marie KARTAL Murat CSOLLEI Marek DOLEŽAL Karel
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Journal of Natural Products
MU Faculty or unit	Faculty of Science
Citation
Web	DOI: 10.1021/np900681y
Field	Biochemistry
Keywords	cytotoxic; flavanones; Paulownia tomentosa; Morus alba; geranyl substitution
Description	Nine geranylated flavanones isolated from the fruits of Paulownia tomentosa and two from the roots of Morus alba were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin, naringenin, and hesperetin and with the standard anticancer drugs olomoucine II, diaziquone, and oxaliplatin and the antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effects of structural changes on cytotoxic activity, including geranyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed.
Related projects:	Proteins in metabolism and interaction of organisms with the environment