LC with off-line MALDI mass spectrometry for analysis of bioactive compounds

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Authors	HÉGROVÁ Blanka PEŠ Ondřej YEUNG Edward S. PREISLER Jan
Year of publication	2010
Type	Article in Proceedings
Conference	X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků
MU Faculty or unit	Faculty of Science
Citation
Field	Analytic chemistry
Keywords	LC; off-line spojení; hmotnostní spektrometrie; nepolární látky
Description	Biologically active compounds include an important class of a large number of polar and nonpolar compounds, which influence significantly organisms. MALDI mass spectrometry is a commonly used technique for analysis of polar biopolymers with detection limits going down to amol levels. Ionization of nonpolar compounds, such as sterols in positive mode was performed by silver ion cationization using silver nanoparticles as the MALDI matrix.
Related projects:	Molecular basis of cell and tissue regulations Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine Multidetection platform for microcolumn separation of proteins and peptides