Cyclic nitrones linked to polycyclic aromatic hydrocarbons as a novel approach to DNA intercalators: synthesis and docking studies

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Authors	BUCHLOVIČ Marian KŘÍŽ Zdeněk POTÁČEK Milan
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	We present a synthesis of new derivatives of PAHs that are coupled together with functionalized five-membered cyclic nitrones via a C=C spacer. Synthetic protocol is based on our experience in the allenyloxime chemistry. We examined the effect on calculated DNA intercalation parameters that reflected the interaction of the functionalized nitrone moiety with DNA backbone.
Related projects:	Allenyl synthon in synthesis of heterocyclic compounds Syntéza nových inhibotorů replikace DNA