Clotting factors and eicosanoids protect against nematode infections

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Authors	HYRŠL Pavel DOBEŠ Pavel WANG Zhi HAULING Thomas WILHELMSSON Christine THEOPOLD Ulrich
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Journal of Innate Immunity
MU Faculty or unit	Faculty of Science
Citation
Field	Immunology
Keywords	Drosophila melanogaster; eicosanoids; entomopathogenic nematodes; Heterorhabditis bacteriophora; transglutaminase; coagulation; Photorhabdus luminescens
Description	We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together our results confirm the conserved nature of the immune function of clot formation.
Related projects:	The influence of the eicosanoid biosynthesis inhibitors to immunity of the wax moth Galleria mellonella