The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin

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Authors	KUBICEK Karel GRIMM S. Kaspar ORTS Julien SASSE Florenz CARLOMAGNO Teresa
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Angewandte Chemie International Edition
MU Faculty or unit	Faculty of Science
Citation
Web	http://onlinelibrary.wiley.com/doi/10.1002/anie.200906828/abstract
Field	Biophysics
Keywords	conformation analysis;cytotoxicity;microtubules;NMR spectroscopy;tubulysin
Description	Bound to be active: The solution structure of tubulin-bound tubulysin A is determined from transferred NOE data (see picture; blue N, red O, yellow S, green C), and this bioactive conformation is compared to the unbound conformation. The binding site on tubulin is examined on the basis of the interligand NOEs observed between epothilone A and tubulysin A in the presence of tubulin.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Biofyzikální výzkum struktur a funkcí biomolekul