The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Physiological Research |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.biomed.cas.cz/physiolres/2010/S1_10.htm |
| Field | Physiology |
| Keywords | Bupivacaine;Lidocaine;Isolated rat heart;Cardiotoxicity;QRS duration |
| Description | Bupivacaine is a widely used long-acting local anaesthetic. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity. Experiments were performed on 21 adult male rats divided into three groups: B (6 mu g/ml bupivacaine), BL (6 mu g/ml bupivacaine and 12 mu g/ml lidocaine) and L (12 mu g/ml lidocaine). The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at constant pressure and the heart rate, PQ and QRS intervals were measured. The present study shows that the mixture of tested local anaesthetics - bupivacaine and lidocaine - impairs the intraventricular conduction parameters (QRS interval prolongation) to a lesser extent than bupivacaine itself, and that this effect is marked mainly at the beginning of perfusion. |
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