1H, 13C, and 15N chemical shift assignments of ZCCHC9

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Authors	SAŇUDO ARCE Maria JACKO Martin RAMMELT Christiane VAŇÁČOVÁ Štěpánka ŠTEFL Richard
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Biomolecular NMR Assignments
MU Faculty or unit	Faculty of Science
Citation
web	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049224/
Doi	http://dx.doi.org/10.1007/s12104-010-9257-2
Field	Genetics and molecular biology
Keywords	ZCCHC9; Zinc knuckle; CCHC; RNA degradation
Description	ZCCHC9 is a human nuclear protein with sequence homology to yeast Air1p/Air2p proteins which are RNA-binding subunits of the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex involved in nuclear RNA quality control and degradation in yeast. The ZCCHC9 protein contains four retroviral-type zinc knuckle motifs. Here, we report the NMR spectral assignment of the zinc knuckle region of ZCCHC9. These data will allow performing NMR structural and RNA-binding studies of ZCCHC9 with the aim to investigate its role in the RNA quality control in human.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Structural studies of protein-RNA complexes involved in RNA quality control EMBO Young Investigator Programme EMBO Young Investigator Programme Program developing interdisciplinary research POtential for the STudies of BIOMolecular INteractions Polyadenylation and mechanisms of nuclear RNA quality control Structural studies of protein-RNA complexes involved in RNA quality control Structural basis for transcription termination of nonpolyadenylated transcripts Strukturní podstata ukončení transkripce nezávislé na poly(A) signálu