Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes

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Authors	BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal OHLÍDALOVÁ Dana JANSOVÁ Dagmar ŠIMURDOVÁ Milena ŠIMURDA Jiří
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Acta Physiologica
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.1111/j.1748-1716.2010.02162.x
Field	Physiology
Keywords	ethanol; action potential; sodium current; calcium current; transient outward potassium current; rat ventricular myocytes
Description	Ethanol reversibly decelerated the upstroke velocity and decreased AP amplitude and duration at 0.2 and 3 Hz. The fast sodium current INa, L-type calcium current ICa and transient outward potassium current Ito were reversibly inhibited in a concentration-dependent manner.As a consequence of marked differences in nH, sensitivity of the currents to ethanol at 10%-inhibition decreases in the following order: ICa (75 mM, 3.5 promile), Ito (170 mM, 7.8 promile) and INa (220 mM, 10.1 promile).
Related projects:	Early diagnostics and treatment of cardiovascular diseases