Bacteriocinogeny in experimental pigs treated with short-term high-dose indomethacin with or without probiotic bacteria Escherichia coli Nissle 1917
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Wourld Journal of Gastroenterology |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.3748/wjg.v17.i5.609 |
| Field | Microbiology, virology |
| Keywords | Bacteriocinogeny; Escherichia coli Nissle 1917; Experimental pigs; Indomethacin |
| Description | AIM: To evaluate bacteriocinogeny in short-term high-dose indomethacin administration with or without probiotic Escherichia coli Nissle 1917 (EcN) in experimental pigs. METHODS: Twenty-four pigs entered the study: Group A (controls), Group B (probiotics alone), Group C (indomethacin alone) and Group D (probiotics and indomethacin). EcN (3.5x1010 bacteria/d for 14 d) and/or indomethacin (15 mg/kg per day for 10 d) were administrated orally. Anal smears before and smears from the small and large intestine were taken from all animals. Bacteriocin production was determined with 6 different indicator strains. RESULTS: The general microbiota profile was rather uniform in all animals but there was a broad diversity in coliform bacteria (parallel genotypes A, B1, B2 and D found). CONCLUSION: EcN did not exert long-term liveability in the porcine intestine. All experimental pigs remained methanogenic. Indomethacin and EcN administered together might produce the worst impact on bacteriocinogeny. |
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