Abnormální metabolizmus thiaminu u DM jako důsledek funkčního deficitu pentózového cyklu a vztah k progresi diabetické nefropatie a mortalitě

Krusová,  Darja; Pácal,  Lukáš; Kaňková,  Kateřina; Svojanovský,  Jan; Tomandl,  Josef; Olšovský,  Jindřich

Abnormální metabolizmus thiaminu u DM jako důsledek funkčního deficitu pentózového cyklu a vztah k progresi diabetické nefropatie a mortalitě

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Title in English	Abnormal thiamin metabolism caused by functional deficit of pentose phoshate cycle and relation to progression of diabetic nephropathy and mortality
Authors	KRUSOVÁ Darja PÁCAL Lukáš KAŇKOVÁ Kateřina SVOJANOVSKÝ Jan TOMANDL Josef OLŠOVSKÝ Jindřich
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	The results support the role of functional thiamine deficiency in the development of hyperglycaemia- related pathology. Limited intracellular availability of active TKT co-factor seems to be a dominant abnormality.
Related projects:	Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy