Variabilita v genech pro Toll-like receptory a jejich vztah k výskytu parodontálních patogenů u chronické parodontitidy

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Title in English	Variability in Toll-like receptor genes and their relation to occurrence of peridontal pathogens in chronic periodontitis
Authors	IZAKOVIČOVÁ HOLLÁ Lydie HRDLIČKOVÁ Barbara VOKURKA Jan AUGUSTÍN Peter FASSMANN Antonín VANĚK Jiří
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Česká stomatologie
MU Faculty or unit	Faculty of Medicine
Citation
Field	ORL, ophthalmology, stomatology
Keywords	periodontitis; gene; polymorphism; bacteria; association; haplotype
Description	Toll-like receptors (TLRs) belong to the pattern recognition receptor family of signal molecules that recognize heterogeneous antigens. The aim of this study was to analyze polymorphisms in the TLR genes and their association with the presence of selected periodontal pathogens and clinical manifestation of chronic periodontitis (CP). In conclusion, these findings suggest that TLR-9 haplotypes may be associated with susceptibility to chronic periodontitis and indicate a possible interaction between the occurrence of some bacteria in the subgingival plaque and polymorphisms in the TLR-4 gene; this finding is in agreement with multifactorial etiology of this disease.
Related projects:	Dental research centre Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu