Correlation of gene expression with centrosome amplification in multiple myeloma
| Authors | |
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| Year of publication | 2011 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Centrosome amplification (CA) may lead to genomic instability of malignant plasma cells in multiple myeloma (MM). Study objective was to evaluate association of CA with expression of genes controlling centrosome duplication. In this study, we showed close interaction between presence of CA and expression of genes controlling centrosome duplication (PCNT, AURKB, AURKA, CCNB2, PLK4, HMMR, TACC3). Some of these genes (AURKA, PCNT and TACC3) reflect even CA positivity of patients. |
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