Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects
Authors | |
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Year of publication | 2012 |
Type | Article in Periodical |
Magazine / Source | International Journal of Obesity |
MU Faculty or unit | |
Citation | |
web | http://www.nature.com/ijo/journal/v36/n2/full/ijo2011101a.html |
Doi | http://dx.doi.org/10.1038/ijo.2011.101 |
Field | Endocrinology, diabetology, metabolism, nutrition |
Keywords | Adipose tissue; thyroid hormones; deiodinases; tissue expression; enzyme activity |
Description | Expression of the genes for type I iodothyronine 5'-deiodinase (D1), leptin (LEP) and stearoyl-CoA desaturase 1 (SCD-1) was evaluated in omental (OM) and subcutaneous (SC) fat using a cohort of 70 humans. Activities of iodothyronine deiodinases (D1, D2 and D3) were assessed in a randomly selected subpopulation of 19 subjects. |
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