Role of HMGB Proteins in Chromatin Dynamics and Telomere Maintenance in Arabidopsis thaliana

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Authors	PROCHÁZKOVÁ SCHRUMPFOVÁ Petra FOJTOVÁ Miloslava MOKROŠ Petr GRASSER Klaus D. FAJKUS Jiří
Year of publication	2011
Type	Article in Periodical
Magazine / Source	CURRENT PROTEIN & PEPTIDE SCIENCE
MU Faculty or unit	Central European Institute of Technology
Citation
Field	Genetics and molecular biology
Keywords	TRANSCRIPTION FACTOR DOF2; MOBILITY GROUP PROTEINS; DNA-BINDING; MAMMALIAN TELOMERES; METHYLATION; HETEROCHROMATIN; RNA; PLANTS; STRESS; REPAIR
Description	HMGB proteins play important role in dynamic changes of chromatin structure. Here, we summarise the roles of plant HMGB proteins in regulation of chromatin structure and dynamics and report on the newly identified role of AtHMGB1 protein in the regulation of plant telomere length. Astonishingly, contrary to mice mHMGB1 homologue, AtHMGB1 does not affect telomerase activity and AtHMGB1 loss or overexpression does not cause any obvious changes in chromatin architecture.
Related projects:	Molecular basis of cell and tissue regulations Understanding of HMGB1 protein involvement in maintaining genome stability Characterisation of functional diversity of the plant-specific SMH family of proteins