Bilateral elevation of TNFa and IL-6 mRNAs in dorsal root ganglia alongside neuroaxis following unilateral nerve injury

Brázda,  Václav; Klusáková,  Ilona; Hradilová Svíženská,  Ivana; Dubový,  Petr

Bilateral elevation of TNFa and IL-6 mRNAs in dorsal root ganglia alongside neuroaxis following unilateral nerve injury

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Authors	BRÁZDA Václav KLUSÁKOVÁ Ilona HRADILOVÁ SVÍŽENSKÁ Ivana DUBOVÝ Petr
Year of publication	2011
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Cytokines are injury-induced inflammatory mediators that contribute to both induction and maintenance of neuropathic pain. We used in situ hybridization and quanitative RT-PCR to provide evidence that unilateral chronic constriction injury (CCI) of the sciatic nerve induces synthesis of TNFa and IL-6 in DRG of different spinal cord segments alongside neuroaxis.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.