DNA hypomethylation increases telomerase activity, but does not change telomere lengths in plants

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Authors	MAJEROVÁ Eva MOZGOVÁ Iva OGROCKÁ Anna FOJTOVÁ Miloslava FAJKUS Jiří
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	Not only the telomeres are chromatin structures, but their maintenance is also co-regulated by the dynamics of their chromatin structure. Several reports showed that the length of telomeres in mouse is negatively influenced by DNA and histone epigenetic marks typical for heterochromatin. Here we studied the effect of hypomethylating drugs on telomere maintenance in plants, which show much higher complexity of epigenetic pathways compared to mammals.
Related projects:	Molecular basis of cell and tissue regulations Understanding of HMGB1 protein involvement in maintaining genome stability Vliv struktury chromatinu na regulaci telomer