Prognostic significance of morphological assessment of plasma cells in multiple myeloma.

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Authors

AL-SAHMANI Mohamed Abdo Saleh TRNAVSKÁ Irena ŠEVČÍKOVÁ Sabina ANTOSOVA M. ANTOSOVA L. KISSOVA J. ADAM Zdeněk POUR Luděk NĚMEC Pavel GREŠLIKOVÁ Henrieta KREJČÍ Marta ZAHRADOVÁ Lenka BULIKOVÁ Alena PENKA Miroslav HÁJEK Roman

Year of publication 2011
Type Article in Periodical
Magazine / Source Neoplasma
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.4149/neo_2011_06_554
Field Oncology and hematology
Keywords multiple myeloma; morphology; plasma cells; cytogenetics; prognostic significance; nucleus
Description Multiple myeloma (MM) is a hematological malignancy caused by clonal proliferation of malignant plasma cells (PC). The aim of the work is to determine prognostic significance of morphological subtypes of PC in relation to overall treatment response, long-term survival and other conventional prognostic parameters. One hundred and thirty-nine newly diagnosed MM patients who underwent autologous transplantation in clinical trials conducted in one center were included. Our work brings valuable prognostic information and correlation with other prognostic factors as well as total treatment response and survival in MM patients who underwent autologous transplantation.
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