Does repetitive transcranial magnetic stimulation have a positive effect on working memory and neuronal activation in treatment of negative symptoms of schizophrenia?

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Authors	PŘIKRYL Radovan MIKL Michal PŘIKRYLOVÁ KUČEROVÁ Hana USTOHAL Libor KAŠPÁREK Tomáš MAREČEK Radek VRZALOVÁ Michaela ČEŠKOVÁ Eva VANÍČEK Jiří
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Neuroendocrinology Letters
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.ncbi.nlm.nih.gov/pubmed/22467118
Field	Psychiatry, sexuology
Keywords	cognitive functions; fMRI; neuronal activation; negative symptoms;
Attached files	NEL_rTMS_negSCH_fMRI_2012.pdf
Description	Stimulation treatment led to a reduction of seriousness of negative schizophrenia symptoms in both comparative groups. However, mutual comparison of real (n=19) and sham (n=11) rTMS, respectively, has shown that the effect of real rTMS was statistically significantly higher compared with placebo stimulation. During stimulation treatment an improvement in working memory performance was also found. No statistically significant difference between the real and placebo sham rTMS, respectively, was established. The rate of neuronal activation did not change at all during rTMS treatment.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions. Funkční mozkové koreláty související s léčbou negativních příznaků schizofrenie repetitivní transkraniální magnetickoustimulací