Nestin expression in high-grade osteosarcomas and its clinical significance

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Authors	ZAMBO Iva HERMANOVÁ Markéta ADÁMKOVÁ KRÁKOROVÁ Dagmar MÚDRY Peter ZITTERBART Karel KÝR Michal VESELÝ Karel ŠTĚRBA Jaroslav VESELSKÁ Renata
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Oncology Reports
MU Faculty or unit	Faculty of Medicine
Citation
Doi	http://dx.doi.org/10.3892/or.2012.1687
Field	Oncology and hematology
Keywords	osteosarcoma; nestin; prognosis; immunohistochemistry; immunofluorescence
Attached files	Oncol_Rep_Early_Online_or_2012_1687.pdf
Description	Using immunohistochemistry and immunofluorescence, we evaluated nestin expression in tumor tissue samples from 45 patients with high-grade osteosarcomas. High levels of nestin expression detected by immunofluorescence were associated with worse clinical outcomes. However, high levels of nestin expression detected by immunohistochemistry trended towards shorter OS and EFS but did not reach statistical significance. Nestin does not seem to represent a powerful prognostic marker for patients with high-grade osteosarcomas.
Related projects:	Molecular basis of cell and tissue regulations