Triple-negativní karcinom prsu: analýza souboru pacientek diagnostikovaných a/nebo léčených v Masarykově onkologickém ústavu v letech 2004 až 2009

Title in English	Triple-negative breast cancer: analysis of patients diagnosed and/or treated at the Masaryk Memorial Cancer Institute between 2004 and 2009.
Authors	SVOBODA Marek NAVRÁTIL Jiří FABIAN Pavel PALÁCOVÁ Markéta GOMBOŠOVÁ Jana SLÁMOVÁ L. PRINC Denis SYPTÁKOVÁ Blažena KUDLÁČEK Aleš BÍLEK Ondřej POSPÍŠIL P. KAZDA Tomáš GRELL Peter POPRACH Alexandr SELINGEROVÁ Iveta NENUTIL Rudolf JURÁČEK Jaroslav HÉŽOVÁ Renata SLABÝ Ondřej VYZULA Rostislav
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Klinická onkologie
Citation
Field	Oncology and hematology
Keywords	triple-negative breast cancer; epidemiology; cytokeratin 5/6; Ki-67 protein; chemotherapy
Description	Triple-negative breast cancer (TNBC) represents a heterogeneous group of breast cancers that do not express ER-alfa, PgR and Her-2 receptors. Generally, these tumors are aggressive and more common in younger women, in which an association of TNBC with mutations in the BRCA1 gene was documented. The aim of our study was to create a representative group of patients with TNBC, which could be analyzed and the data gathered to build basic epidemiological, molecular and clinical characteristics of Czech patients with TNBC.