Alleviation of extrapyramidal side effects upon switching from risperidone to paliperidone

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Authors	PŘIKRYL Radovan
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Activitas Nervosa Superior Rediviva
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.rediviva.sav.sk/53i1/14.pdf
Field	Psychiatry, sexuology
Keywords	case report; clinical experience; extrapyr amidal side effects; paliperidone; treatment
Description	Paliperidone is a new second generation antipsychotic; in terms of pharmacology, it is an active metabolite of risperidone. Compared to risperidone, paliperidone should thus show more stable occupation of dopamine receptors in the brain, which on one the hand may lead to increased antipsychotic efficacy, and on the other hand to reduced incidence of adverse extrapyramidal effects. The case report describes alleviation of Parkinson’s syndrome induced by risperidone by switching to paliperidone in a young man with a new occurrence of a paranoid schizophrenia episode. Thanks to its clinical efficacy, paliperi- done is ranked among the most successful second generation antipsychotics with reduced extrapyramidal symptomatology
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.