Default Mode Network and Extrastriate Visual Resting State Network in Patients with Parkinson's Disease Dementia
| Autoři | |
|---|---|
| Rok publikování | 2012 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Neurodegenerative Diseases |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.karger.com/Article/Abstract/334765 |
| Doi | http://dx.doi.org/10.1159/000334765 |
| Obor | Neurologie, neurochirurgie, neurovědy |
| Klíčová slova | Default mode network; Extrastriate visual resting state network; Parkinson's disease dementia; Functional connectivity |
| Popis | Aims: Using fMRI, we evaluated the default mode network (DMN) and the extrastriate visual resting state network (ESV-RSN) in 14 patients with Parkinson's disease dementia (PDD) as compared with 18 patients with Parkinson's disease (PD) without dementia and 18 healthy controls (HC). Methods: We analyzed the seed-based functional connectivity of both resting state data and deactivations during a visual complex scene-encoding task. Results: Using the posterior cingulate cortex/precuneus as a seed for the DMN analysis, we observed significant decreases of connectivity in the right inferior frontal gyrus in PDD as compared to PD and HC. Using the caudate nucleus as a seed for the ESV-RSN analysis, we found significant decreases of connectivity in the left and right inferior occipital gyrus in PDD as compared to HC. Conclusion: Differences in functional connectivity patterns between PDD and PD/HC were observed in areas known to be engaged in stimulus-driven reorienting of attention and in visual processing. Copyright (C) 2012 S. Karger AG, Basel |
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