Blood levels of heavy metals and metallothionein in type 2 diabetics with kidney disease

Autoři	PÁCAL Lukáš DVOŘÁKOVÁ Veronika RAUDENSKÁ Martina KURICOVÁ Katarína GUMULEC Jaromír SVOJANOVSKÝ Jan ŘEHOŘOVÁ Jitka RUTTKAY-NEDECKÝ Branislav ZÍTKA Ondřej KIZEK René MASAŘÍK Michal KAŇKOVÁ Kateřina
Rok publikování	2013
Druh	Konferenční abstrakty
Citace
Popis	Oxidative stress and subsequent activation of antioxidant mechanisms (both enzymatic and nonenzymatic) is well established in type 2 diabetes (T2DM). Metallothionein (MT) is a protein binding heavy metal ions (primarily zinc). MT substantially affects zinc metabolism and thus insulin secretion by beta-cell. Zinc levels are often decreased in diabetics due to its increased renal clearance. Association of polymorphism in the gene for zinc transporter (ZnT-8) with T2DM in genome wide association study (Sladek R et al. Nature 2007) underlines the role of zinc for glucose metabolism. We aimed to determine blood levels of selected heavy metals, MT, antioxidants and relevant SNPs in type 2 diabetics with kidney disease (at least microalbuminuric) and healthy subjects.
Související projekty:	Pentózový cyklus jako potenciální nový terapeutický cíl v prevenci diabetických komplikací