Using NMR spectroscopy for improvement of cisplatin-based drugs

Varování

Publikace nespadá pod Ústav výpočetní techniky, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	ŠMIŘÁKOVÁ Eliška PAPADIA Paride ARNESANO Fabio NATILE Giovanni KUBÍČEK Karel KOZELKA Jiří
Rok publikování	2011
Druh	Konferenční abstrakty
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Popis	One of the aims of the present research is the development of new anticancer drugs by modifying the already known ones to increase their cytostatic activity while lowering the side-effects. The major goal of this project is to investigate the sequence selectivity of cisplatin-DNA interaction in order to understand the biochemical mechanism of cisplatin effect and consider the way to reduce its toxicity. To achieve this goal, we employed modern NMR methods, taking so the advantage of the fact that it is possible to study the biological compounds of interest in solution under nearly physiological conditions. In my contribution, I will show the structural properties of DNA 22-mer containing T4-loop crosslinked with cisplatin derivative RR-DACH. NMR data acquisition and processing as well as the determination of the structural models using molecular dynamics simulations will be presented.
Související projekty:	Biofyzikální výzkum struktur a funkcí biomolekul