Both ketamine and NBQX attenuate alcohol drinking in male Wistar rats
Název česky | Ketamin i NBQX potlačují pití alkoholu u potkaních samců kmene Wistar |
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Autoři | |
Rok publikování | 2018 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Neuroscience Letters |
Fakulta / Pracoviště MU | |
Citace | |
www | https://www.sciencedirect.com/science/article/pii/S030439401731025X |
Doi | http://dx.doi.org/10.1016/j.neulet.2017.12.055 |
Obor | Farmakologie a lékárnická chemie |
Klíčová slova | Alcoholism; Alcohol use disorder; Glutamatergic receptors; NMDA receptor; AMPA receptor; Kainate receptor |
Popis | Highlights: Acute low dose ketamine reduced alcohol intake but not alcohol-related behavioural effects. Acute low dose NBQX reduced alcohol intake but not alcohol-related behavioural effects. NMDA or AMPA/kainate receptor antagonists may have treatment potential in alcohol use disorder. These results suggest that selective antagonism of the NMDA or AMPA/kainate receptors may be of therapeutic potential in AUD. |
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