DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS

Varování

Publikace nespadá pod Ústav výpočetní techniky, ale pod Farmaceutickou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	ONUŠČÁKOVÁ Magdaléna PÍŽOVÁ Hana KAUEROVÁ Tereza HAMŠÍKOVÁ Marie BEDNÁŘ David KOLLÁR Peter BOBÁĽ Pavel
Rok publikování	2022
Druh	Článek ve sborníku
Konference	Czech Chemical Society Symposium Series
Fakulta / Pracoviště MU	Farmaceutická fakulta
Citace
www	http://www.ccsss.cz/index.php/ccsss/issue/view/31/45
Klíčová slova	HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer
Popis	Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking.
Související projekty:	Analýza antiproliferačních, proapoptotických a cytodiferenciačních účinků nově syntetizovaných hydroxamových kyselin Design, synthesis and evaluation of potential metalloenzymes inhibitors