The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years' experience of association studies to understand the genetic architecture of pancreatic cancer

• Autoři: CAMPA D.; GENTILUOMO M.; STEIN A.; AOKI M. N.; OLIVERIUS M.; VODIČKOVÁ L.; JAMROZIAK K.; THEODOROPOULOS G.; PASQUALI C.; GREENHALF W.; ARCIDIACONO P. G.; UZUNOGLU F.; PEZZILLI R.; LUCHINI C.; PUZZONO M.; LOOS M.; GIACCHERINI M.; KATZKE V.; MAMBRINI A.; KIUDELIENE E.; FEDERICO K. E.; JOHANSEN J.; HUSSEIN T.; MOHELNIKOVA-DUCHONOVA B.; VAN EIJCK C. H. J.; BRENNER H.; FARINELLA R.; PÉREZ J. S.; LOVECEK M.; BÜCHLER M. W.; HLAVAC Viktor; IZBICKI J. R.; HACKERT T.; CHAMMAS R.; ZERBI A.; LAWLOR R.; FELICI A.; GÖTZ M.; CAPURSO G.; GINOCCHI L.; GAZOULI M.; KUPCINSKAS J.; CAVESTRO G. M.; VODICKA Pavel; MOZ S.; NEOPTOLEMOS J. P.; KUNOVSKÝ Lumír; BOJESEN S. E.; CARRARA S.; GIOFFREDA D.; MORKUNAS E.; ABIAN O.; BUNDUC S.; BASSO D.; BOGGI U.; WLODARCZYK B.; SZENTESI A.; VANELLA G.; CHEN I.; BIJLSMA M. F.; KIUDELIS V.; LANDI S.; SCHÖTTKER B.; CORRADI C.; GIESE N.; KAAKS R.; PEDUZZI G.; HEGYI P.; MORELLI L.; FURBETTA N.; SOUCEK Pavel; LATIANO A.; TALAR-WOJNAROWSKA R.; LINDGAARD S. C.; DIJK F.; MILANETTO A. C.; TAVANO F.; CERVENA Klara; ERŐSS B.; TESTONI S. G.; VERHAGEN-OLDENAMPSEN J. H. E.; MAŁECKA-WOJCIESKO E.; COSTELLO E.; SALVIA R.; MAIELLO E.; ERMINI S.; SPERTI C.; HOLLECZEK B.; PERRI F.; SKIECEVICIENE J.; ARCHIBUGI L.; LUCCHESI M.; RIZZATO C.; CANZIAN F.
• Rok publikování: 2023
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Critical reviews in oncology/hematology
• Fakulta / Pracoviště MU: Lékařská fakulta
• www: https://www.sciencedirect.com/science/article/pii/S1040842823001087?via%3Dihub
• Doi: http://dx.doi.org/10.1016/j.critrevonc.2023.104020
• Klíčová slova: Pancreatic cancer; Pancreatic ductal adenocarcinoma; Pancreatic neuroendocrine tumors; Intraductal papillary mucinous neoplasms; Chronic pancreatitis; Genetic epidemiology; Consortium

Přiložené soubory

• The_PANcreatic_Disease_ReseArch__PANDoRA__consortium_Ten_years__experience_of_association_studies_to_understand_the_genetic_architecture_of_pancreatic_cancer.pdf

• Popis: Pancreatic cancer has an incidence that almost matches its mortality. Only a small number of risk factors and 33 susceptibility loci have been identified. so Moreover, the relative rarity of pancreatic cancer poses significant hurdles for research aimed at increasing our knowledge of the genetic mechanisms contributing to the disease. Additionally, the inability to adequately power research questions prevents small monocentric studies from being successful. Several consortia have been established to pursue a better understanding of the genetic architecture of pancreatic cancers. The Pancreatic disease research (PANDoRA) consortium is the largest in Europe. PANDoRA is spread across 12 European countries, Brazil and Japan, bringing together 29 basic and clinical research groups. In the last ten years, PANDoRA has contributed to the discovery of 25 susceptibility loci, a feat that will be instrumental in stratifying the population by risk and optimizing preventive strategies.

Související projekty

• Národní ústav pro výzkum rakoviny