Mouse molar development and the role of mechanosensation in the root formation
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| Rok publikování | 2022 |
| Druh | Konferenční abstrakty |
| Citace | |
| Popis | Mouse dentition is characterized by one hypselodont (continuously growing) incisor and a set of three brachydont molars (M1, M2, and M3) anchored to the alveolar bone in each quadrant. Alike human teeth, mouse molars finish their growth once they reach the occlusion and exhibit only a limited reparative capacity. Due to these similarities, mouse molars, and specifically M1, is widely used as a convenient and attractive model for studying odontogenesis. Even though the histology and developmental aspects of the molar´s morphogenesis are well described, there is still a lack of information about the dynamics and regulation of molar development and growth during the early prenatal and postnatal (P) stages. Here, we presented a detailed insight of development of mouse molars. We have monitored crown and root growth at different timepoints from birth until adulthood to uncover the development of molars in 3D and time. Specifically, we have focused on crown development (P0-P6), root patterning (P6-P12), and root elongation (P12-P30). Finally, we explored the differences in the M1 morphology in relation to the food hardness. Our results suggest an important role of mechanosensation in the regulation of molar roots´ length and dentin thickening. |
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