Structural conservation of antibiotic interaction with ribosomes
Autoři | |
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Rok publikování | 2023 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | NATURE STRUCTURAL & MOLECULAR BIOLOGY |
Fakulta / Pracoviště MU | |
Citace | |
www | https://www.nature.com/articles/s41594-023-01047-y |
Doi | http://dx.doi.org/10.1038/s41594-023-01047-y |
Klíčová slova | ribosome; antibiotics; CryoEM; antibiotic–ribosome interactions; RNA-targeting therapies |
Popis | Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new antibacterial agents. Their results unveil a conserved manner of antibiotic binding to the ribosome, including ordered water molecules. |
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