Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives
| Autoři | |
|---|---|
| Rok publikování | 2024 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | PLANTS-BASEL |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://pubmed.ncbi.nlm.nih.gov/38732396/ |
| Doi | http://dx.doi.org/10.3390/plants13091181 |
| Klíčová slova | AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine |
| Popis | Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors. |
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