The effect of controlled physical activity on the activity and balance of the autonomic nervous system in cancer patients
| Název česky | Vliv řízené pohybové aktivity na činnost a rovnováhu autonomního nervového systému u onkologických pacientů |
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| Autoři | |
| Rok publikování | 2024 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | The autonomic nervous system (ANS), frequently compromised by cancer and its treatment modalities, can be evaluated through heart rate variability (HRV) monitoring. Chemotherapeutic agents, particularly vinca alkaloids, platinum compounds, and taxanes, are known to adversely affect the nervous system. While previous studies have suggested a potential positive influence of physical activity on HRV, the results remain inconclusive and are predominantly based on single-point HRV measurements. This study aims to conduct continuous HRV monitoring over a 12-week period in cancer patients following adjuvant chemotherapy and to assess the impact of a structured exercise intervention program (EIP) on HRV parameters. Participants, comprising cancer patients who have undergone specific adjuvant chemotherapy regimens, are randomized into experimental (SAPA) and control (CO) groups. The SAPA group is engaged in thrice-weekly online supervised exercise sessions via ZOOM for 12 weeks, with intensity maintained at 60-80% of VO2max. Exercise intensity is determined through spiroergometric testing and monitored using heart rate monitors. Participants are asked to record their HRV thrice weekly utilizing chest strap heart rate monitors in conjunction with a specialized mobile application. The primary outcomes of this study will include long-term monitoring of HRV parameters and a comparative analysis of the effect of physical activity on these parameters. Secondary outcomes will encompass monitoring the effect of exercise intensity on HRV parameters (adherence to required intensity) and assessing changes in participants' aerobic fitness (VO2max). This comprehensive approach aims to provide more robust evidence regarding the potential benefits of structured physical activity on autonomic function in cancer survivors post-chemotherapy. |
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