Maternal depression during the perinatal period and its relationship with emotion regulation in young adulthood: An fMRI study in a prenatal birth cohort

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Publikace nespadá pod Ústav výpočetní techniky, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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MAREČKOVÁ Klára TRBUŠEK Filip MAREČEK Radek CHLÁDEK Jan KOSCOVA Zuzana PLESINGER Filip ANDRÝSKOVÁ Lenka BRÁZDIL Milan NIKOLOVA Yuliya S

Rok publikování 2025
Druh Článek v odborném periodiku
Časopis / Zdroj Psychological Medicine
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://www.cambridge.org/core/journals/psychological-medicine/article/maternal-depression-during-the-perinatal-period-and-its-relationship-with-emotion-regulation-in-young-adulthood-an-fmri-study-in-a-prenatal-birth-cohort/75C2C3BA7C41DE755E09E97BBCE961
Doi http://dx.doi.org/10.1017/S0033291725000042
Klíčová slova emotion regulation; fMRI; heart rate variability; maternal perinatal depression; prenatal birth cohort; skin conductance
Popis Background Maternal perinatal mental health is essential for optimal brain development and mental health of the offspring. We evaluated whether maternal depression during the perinatal period and early life of the offspring might be selectively associated with altered brain function during emotion regulation and whether those may further correlate with physiological responses and the typical use of emotion regulation strategies.Methods Participants included 163 young adults (49% female, 28-30 years) from the ELSPAC prenatal birth cohort who took part in its neuroimaging follow-up and had complete mental health data from the perinatal period and early life. Maternal depressive symptoms were measured mid-pregnancy, 2 weeks, 6 months, and 18 months after birth. Regulation of negative affect was studied using functional magnetic resonance imaging, concurrent skin conductance response (SCR) and heart rate variability (HRV), and assessment of typical emotion regulation strategy.Results Maternal depression 2 weeks after birth interacted with sex and showed a relationship with greater brain response during emotion regulation in a right frontal cluster in women. Moreover, this brain response mediated the relationship between greater maternal depression 2 weeks after birth and greater suppression of emotions in young adult women (ab = 0.11, SE = 0.05, 95% CI [0.016; 0.226]). The altered brain response during emotion regulation and the typical emotion regulation strategy were also as sociated with SCR and HRV.Conclusions These findings suggest that maternal depression 2 weeks after birth predisposes female offspring to maladaptive emotion regulation skills and particularly to emotion suppression in young adulthood.
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