The reactivity of N3-Aryl-N1-(2-phenylquinazolin-4-yl)thioureas
| Autoři | |
|---|---|
| Rok publikování | 2001 |
| Druh | Článek ve sborníku |
| Konference | Sborník príspevkov 53. zjazd Chemických spoločností |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Organická chemie |
| Klíčová slova | Quinazolines; thioureas; guanidines |
| Popis | The model compound N3-aryl-N1-(2-phenyl-3,4-dihydroquinazolin-4-yl)thiourea 1 was synthesized in a Domino reaction of N2-(2-cyanophenyl)-N1-thioxomethylidenebenzene-1-carboximidamide with anilines. This compound reacts with alkyl halides, phenacyl bromides, chloroacetic acid derivatives, amines, amines in the presence of H2O2, amines in the presence of CH2O (under Mannich reaction conditions) and acyl halides to give a variety of compounds. The structure of these products together with the reason for there formation proved by quantum computational studies will be reported in this contribution. Compounds were identified by FTIR, 1H NMR, 13C NMR, X-ray, mass spectroscopy and by the ab initio computational. |
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