Gene polymorphisms (G82S,1704G/T, 2184A/G and 2245G/A) in the receptor of advanced glycation end products (RAGE) with plaque psoriasis
| Autoři | |
|---|---|
| Rok publikování | 2002 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Archives of Dermatological Research |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Dermatovenerologie |
| Klíčová slova | RAGE-gene polymorphism-psoriasis-antioxidant status |
| Popis | Having in mind relations between oxidative stress, psoriasis and common disorders, associations of polymorphisms in gene coding for RAGE with plaque psoriasis considering personal history of diabetes mellitus, cardiovascular disorders, cancer and allergy were investigated.Allele frequencies and genotype combinations of the four polymorphisms in RAGE gene (6p 21.3, G82S, 1704G/T, 2184A/G and 2245A/G) were compared in a case-control study comprising 272 subjects (130 patients with plaque psoriasis and 142 healthy control subjects of comparable age and sex distribution). Polymerase chain reaction with subsequent restriction analysis were used for detection of allele variants. No correlations of alleles and/or genotypes of all examined RAGE polymorphism with positive familiar history of psoriasis and/or early onset of psoriasis manifestation (less than 40 years) were found. The G82S, 1704G/T and 2245A/G RAGE polymorphisms were associated neither with plaque psoriasis nor with personal history of common diseases (diabetes mellitus, cardiovascular disorders, cancer, allergy). Statistically significant rise in the 2184G allele frequency of 2184A/G RAGE polymorphism was observed in psoriatics compared to control group (odds ratio 1.40, 95% CI 0.88-2.21, P=0.005, after correction for the number of comparisons Pcorr=0.02). The 2184G allele occurred more often in psoriatic patients with negative personal history of diabetes mellitus (odds ratio 1.07, 95% CI 0.69-1.64, P=0.007) and with negative personal history of cardiovascular diseases (odds ratio 1.7, 95% CI 1.08-2.07, P=0.001). The distribution of common genotypes of the four polymorphisms (81 variants) did not differ signficantly between psoriatic and control group. The identification of novel susceptibility gene RAGE - provides some insight into the precise biochemical pathway that control plaque psoriasis manifestation. Because genetic background of psoriasis is supposed to be multigenic, interaction with other several genes with higher common relative genetic risk for psoriasis manifestation could be expected. Complicated linkage disequilibria within HLA system genes in 6p21.3 region cannot be excluded. |
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