Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature.
| Název česky | Změny IL-6 a jeho receptoru ve spinálních gangliích potkana po ligatuře spinálního nervu. |
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| Autoři | |
| Rok publikování | 2008 |
| Druh | Další prezentace na konferencích |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Robust axon regeneration and neuropathic pain induction occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. The sciatic nerve injury induces up-regulation of IL-6. We were used ligature of spinal nerves for investigation of temporal changes of IL-6 protein and its receptor gp130 in both ipsi- and contralateral lumbal (L4-L5) dorsal root ganglia. The obtained data provide evidence for changes of IL-6 protein levels not only in dorsal root ganglia's associated with damaged nerve, but also in those non-associated with nerve injury in the rat experimental neuropathic pain model. |
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