The effects of TGFb proteins on osteoclast differentiation
| Název česky | Vliv proteinů rodiny TGFb na diferenciaci osteoklastů |
|---|---|
| Autoři | |
| Rok publikování | 2008 |
| Druh | Článek ve sborníku |
| Konference | Proceedings of the abstracts of the 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Genetika a molekulární biologie |
| Klíčová slova | osteoclasts; TGF beta; prostate cancer |
| Popis | Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect the bone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes, such as.In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of osteoclasts. |
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