Determination of the surface pathology of human sperm by atomic force microscopy
| Název česky | Zobrazení patologií povrchu spermie metodou mikroskopie atomových sil0268-1161 |
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| Autoři | |
| Rok publikování | 2010 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Atomic force microscopy (AFM) employs a sharp probe for profiling surfaces with unique resolution. This technique has developed into an invaluable multidisciplinary tool for advanced characterization of different samples. In its basic application, AFM provides high resolution imaging of surface structures at scales ranging from a few nanometers to hundreds micrometers. Oxidative stress is considered one of the basic etiological factors of the male’s fertility disorders. Excessive production of oxygen radicals results in damage to the sperm’s cell membrane and to the DNA. The collected AFM images clearly highlight many details of normal spermatozoa and spermatozoa damaged by hydrogen peroxide. This technique could be an important tool in the research of oxidative stress and understanding its effect on male infertility. |
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