Clustering of Protein Substructures for Discovery of a Novel Class of Sequence-Structure Fragments
| Název česky | Shlukování proteinových substruktur pro nalezení nových sekvenčně-strukturních fragmentů |
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| Autoři | |
| Rok publikování | 2010 |
| Druh | Článek ve sborníku |
| Konference | ITBAM 2010 (Information Technology in Bio- and Medical Informatics), LNCS 6266 |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1007/978-3-642-15020-3_9 |
| Obor | Informatika |
| Klíčová slova | Clustering; density-based clustering; clustering of protein substructures; sequence-structure relationships in proteins |
| Popis | In this paper, we propose a novel method for clustering of protein substructures that we developed to study the relationships between protein sequences and their corresponding structures. We show the basic properties of the new method and the results of the comparison to other commonly used methods for clustering of protein structures. The main advantage of our method is its high efficiency and scalability, which are key factors for analyzing large data sets. Finally, we outline a procedure for finding sequence profiles that tend to occur in more than one structural conformation but the number of their structural conformations is limited. This procedure is based on our method for protein substructure clustering. |
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