Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma
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Rok publikování | 2010 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Hum. Reprod. |
Fakulta / Pracoviště MU | |
Citace | |
Obor | Fyziologie |
Klíčová slova | Seminal plasma; Growth/Differentiation Factor 15 (GDF15/MIC1); FOXP3 |
Popis | The GDF-15 concentration in seminal plasma ranged from 0.2 to 6.6 ug/ml as determined by ELISA. Western blot analysis revealed that GDF-15 is present in the active form. In vitro cultivation of sperm cells with GDF-15 did not affect their viability or rates of apoptosis; however, it did inhibit proliferation of PBMCs and induce expression of FOXP3 in CD4+CD25+ cells. |
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