Comparison of Voltage-Sensitive Dye di-4-ANEPPS Effects in Isolated Hearts of Rat, Guinea Pig, and Rabbit

• Autoři: FIALOVÁ Kateřina; KOLÁŘOVÁ Jana; PROVAZNÍK Ivo; NOVÁKOVÁ Marie
• Rok publikování: 2010
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Computing in Cardiology
• Fakulta / Pracoviště MU: Lékařská fakulta
• www: http://cinc2010.org
• Obor: Fyziologie
• Klíčová slova: isolated heart; voltage-sensitive dye; arrhythmia; rat; guinea pig; rabbit
• Popis: Voltage sensitive dyes (VSDs) are used for recording of monophasic action potentials (MAPs) by optical method in excitable tissues. Their direct effect on the tissue are not completely elucidated. Previously we studied effects of VSD di-4-ANEPPS during staining and washout in Langendorff-perfused guinea pig and rabbit isolated hearts. However, most often used species in basic cardiology is rat. Therefore, we decided to compare the electrophysiological effects of VSD in isolated hearts of rabbit, guinea pig, and rat.

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