The effect of cortical repetitive transcranial magnetic stimulation on cognitive event-related potentials recorded in the subthalamic nucleus.
| Autoři | |
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| Rok publikování | 2010 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Experimental Brain Research |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Neurologie, neurochirurgie, neurovědy |
| Klíčová slova | inferior frontal cortex; subthalamic nucleus; executive functions; ERP; P3; hyperdirect pathway |
| Popis | We studied whether the cognitive event-related potentials (ERP) in the subthalamic nucleus (STN) are modified by the modulation of the inferior frontal cortex (IFC) and the dorsolateral prefrontal cortex (DLPFC) with repetitive transcranial magnetic stimulation (rTMS). Eighteen patients with Parkinson disease who had been implanted with a deep brain stimulation (DBS) electrode were included in the study. The ERPs were recorded from the DBS electrode before and after the rTMS (1 Hz, 600 pulses) over either the right IFC (10 patients) or right DLPFC (8 patients). rTMS over the right IFC led to a shortening of ERP latencies from 277 ms (SD) to 252 ms in the standard protocol and from 296 ms to 270 ms in the protocol modified by a higher load of executive functions. Connections (the IFC-STN hyperdirect pathway) with the cortex that bypass the BG-thalamocortical circuitries could explain the position of the STN in the processing of executive functions. |
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