Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres
Název česky | Kvalita nově vzniklé chrupavčité tkáně v defektu kloubního povrchu po transplantaci MSCs a kompozitního nosiče na základě kolagenu I a chitosanových mikro a nanovláken. |
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Autoři | |
Rok publikování | 2010 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Physiol. Res. |
Fakulta / Pracoviště MU | |
Citace | |
Obor | Traumatologie a ortopedie |
Klíčová slova | bone marrow mesenchymal stem cells;allogeneic;micropicking;articular cartilage |
Popis | It follows from the above-said that treatment of iatrogenic lesions of the surface of articular cartilage on femur condyles in miniature pigs after transplantation of mesenchymal stem cells in a composite scaffold based on collagen I containing micro- and nanofibers from chitosan resulted in filling of tissue defects in a hyaline type of cartilage. Lesions treated by implantation of scaffold alone or by micropicking were filled with fibrous cartilage with inferior macroscopic, histological and immunohistochemical parameters. |
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