Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing
Autoři | |
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Rok publikování | 2011 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Epigenetics |
Fakulta / Pracoviště MU | |
Citace | |
Doi | http://dx.doi.org/10.4161/epi.6.5.15764 |
Obor | Genetika a molekulární biologie |
Klíčová slova | transcriptional gene silencing; transgene epialleles; DNA methylation; small RNA |
Popis | It has been well established that trans-acting small RNAs guide promoter methylation leading to its inactivation and gene silencing at the transcriptional level (TGS).These features contrast with a non-methylated single copy transgenic locus that required several generations of contact with RNA silencing molecules to become imprinted in a stable epiallele. |
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