Project information
The Role of Fos and Jun proteins in RA-driven monocytic differentiation
- Project Identification
- GA301/01/0040
- Project Period
- 1/2001 - 1/2003
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
Malignant transformation results from genetic changes interfering with a cellular signaling network that in healthy cells controls processes of differentiation, proliferation and death to maintain homeostasis. Understanding of the role of key regulators in this network and their interactions is an important step in creation of anti-tumor therapies. Proteins Myb, Fos, Jun and retinoid receptors belong to this group and we wish to determine the role they play in regulation of differentiation and prolifera tion of leukemic cells. We have showed previously that the retinoic acid receptor (RAR) and its dimerization partner (RXR) could act in a dominant, ligand-dependent fashion to suppress leukemic transformation by the v-myb oncogene. Additional preliminary data now suggest that the Jun transcription factor may regulate the differentiation of v-myb-transformed BM2 cells via activation of endogenous retinoic acid receptor pathways. To test this hypothesis directly, we propose to address the following specif
Publications
Total number of publications: 12
2003
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c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts
Cellular and Molecular Life Sciences, year: 2003, volume: 60, edition: 12
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Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
Memory in Living Systems, year: 2003
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Differential roles of Fos and Jun proteins in regulation of differentiation and apoptosis of v-myb-transformed monoblasts
Antibody-based therapeutics for cancer, year: 2003
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Mechanismus suprese onkoproteinu v-myb proteinem jun v buňkách BM2: aktivace receptoru pro kyselinu retinovou
Sborník příspěvků, VII. pracovní setkání biochemiků a molekulárních biologů, year: 2003
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Proteiny Fos: struktura, regulace, úloha v buňce
Biologické listy, year: 2003, volume: 68, edition: 4
2002
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Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts
Cellular and Molecular Life Sciences, year: 2002, volume: 59, edition: 10
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Rozdílné účinky proteinů v-Fos a c-Fos na linii ptačích monoblastů transformovaných onkogenem v-myb
Informační listy Genetické společnosti Gregora Mendela, year: 2002, volume: 18, edition: 24
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The effects of Jun proteins on growth and differentiation of v-myb-transformed monoblasts
Differentiation, year: 2002, volume: 70, edition: 7
2001
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Odlišné účinky virové a buněčné formy proteinu Jun na monoblasty transformované onkogenem v-myb
V. pracovní setkání biochemiků a molekulárních biologů, year: 2001
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v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts
The 17th annual meeting on oncogenes, year: 2001