Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts

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Authors	ŠEVČÍKOVÁ Sabina SOUČEK Karel KUBALA Lukáš BRYJA Vítězslav ŠMARDA Jan
Year of publication	2002
Type	Article in Periodical
Magazine / Source	Cellular and Molecular Life Sciences
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	v-Myb; Jun; differebtiation; proliferation; retinoic acid; phorbol ester
Description	The line of v-myb-transformed chicken monoblats BM2 can be induced to terminal differentiation using phorbol esters. The fact that Jun proteins are up-regulated in the phorbol ester-treated BM2 cells promptred us to investigate the role of the Jun proteins in regulation of myeloid differentiation. We ectopically expressed v-jun and c-jun in BM2 cells and evaluated their effects on differentiation, proliferation and apoptosis.
Related projects:	The Role of Fos and Jun proteins in RA-driven monocytic differentiation Genomes and their functions