Project information
Biomolecular centre
- Project Identification
- LC06030
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Keywords
- Cancer drugs, biosensors, lectins, molecular modeling of biomolecules, biomolecular NMR
- Cooperating Organization
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Institute of Biophysics
- Responsible person prof. RNDr. Jiří Šponer, DrSc.
- Responsible person doc. RNDr. Ivan Rychlík, Ph.D.
The main goal of the project is to elevate the structural biology in the Czech Republic from studies of individual biomacromolecules to investigations of their complexes. This goal will be achieved by implementation of up-to-date methodology in selected scientific fields (NMR spectroscopy, computational modeling) and by focusing on problems, which are currently in the centre of interest of contemporary life sciences. Among others, key cell processes such as preservation of genome stability and DNA repair, ribosomal protein synthesis, or information transfer by recognition (lectins) will be studied. Selected research projects will lead eventually to bioanalytical (biosensors) and biomedical (vaccines, chemotherapeutics) outcomes with potential applications in research and development. To reach the outlined goals, active collaboration of participating institutions is inevitable. A number of projects will require also a broad international collaboration.
Results
The main goal of the project is to help to drive structural biology in the Czech Republic from studies on single biomacromolecules to studies on biomacromolecular complexes. To achieve the goal, we will implement recent advances in selected key methods in the field (NMR spectrometry, computer modeling) and also contribute to their development. The research will be oriented not only to the structure of biomacromolecules but will also include studies of structure/function relationship. It will touch suchimportant phenomena of the cell life as keeping genome stability, DNA repair, protein synthesis in the ribosome or information transfer via recognition (lectins). Selected parts of the research will be devoted to bioanalytical (biosensors) or biomedicinal(vaccines, chemotherapeutics) projects capable of providing results with potential applications at the practical level. By solving the above scientific tasks, the team will increase its international competitiveness. At the same time, the project will
Publications
Total number of publications: 284
2013
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CH-pi Interaction between Carbohydrates and Aromatic Moieties: Electron Density Issue
Year: 2013, type: Conference abstract
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Toward Reproducing Sequence Trends in Phosphorus Chemical Shifts for Nucleic Acids by MD/DFT Calculations
Journal of Chemical Theory and Computation, year: 2013, volume: 9, edition: 3, DOI
2012
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Biotinylation of quantum dots for application in fluoroimmunoassays with biotin-avidin amplification
Microchimica Acta, year: 2012, volume: 176, edition: 3-4, DOI
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Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation.
Nucleic Acids Research, year: 2012, volume: 40, edition: 16, DOI
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Formamide-Based Prebiotic Synthesis of Nucleobases: A Kinetically Accessible Reaction Route
The Journal of Physical Chemistry A, year: 2012, volume: 116, edition: 1, DOI
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Free energy calculation in lectin/saccharide complexes
Year: 2012, type: Conference abstract
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Homologous recombination and its regulation
Nucleic Acids Research, year: 2012, volume: 40, edition: 13, DOI
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Influence of stereochemistry on proton transfer in protonated tripeptide models
Journal of Molecular Modeling, year: 2012, volume: 18, edition: 3, DOI
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Is formamide nature’s choice to create life? Comment on the paper “Formamide and the origin of life” by Raffaele Saladino et al.
PHYSICS OF LIFE REVIEWS, year: 2012, volume: 9, edition: 1, DOI
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Molecular Dynamics Simulations of RNA Molecules
Innovations in Biomolecular Modeling and Simulations, edition: 1. vydání, year: 2012, number of pages: 27 s.