Project information
Biomolecular centre
- Project Identification
- LC06030
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Keywords
- Cancer drugs, biosensors, lectins, molecular modeling of biomolecules, biomolecular NMR
- Cooperating Organization
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Institute of Biophysics
- Responsible person prof. RNDr. Jiří Šponer, DrSc.
- Responsible person doc. RNDr. Ivan Rychlík, Ph.D.
The main goal of the project is to elevate the structural biology in the Czech Republic from studies of individual biomacromolecules to investigations of their complexes. This goal will be achieved by implementation of up-to-date methodology in selected scientific fields (NMR spectroscopy, computational modeling) and by focusing on problems, which are currently in the centre of interest of contemporary life sciences. Among others, key cell processes such as preservation of genome stability and DNA repair, ribosomal protein synthesis, or information transfer by recognition (lectins) will be studied. Selected research projects will lead eventually to bioanalytical (biosensors) and biomedical (vaccines, chemotherapeutics) outcomes with potential applications in research and development. To reach the outlined goals, active collaboration of participating institutions is inevitable. A number of projects will require also a broad international collaboration.
Results
The main goal of the project is to help to drive structural biology in the Czech Republic from studies on single biomacromolecules to studies on biomacromolecular complexes. To achieve the goal, we will implement recent advances in selected key methods in the field (NMR spectrometry, computer modeling) and also contribute to their development. The research will be oriented not only to the structure of biomacromolecules but will also include studies of structure/function relationship. It will touch suchimportant phenomena of the cell life as keeping genome stability, DNA repair, protein synthesis in the ribosome or information transfer via recognition (lectins). Selected parts of the research will be devoted to bioanalytical (biosensors) or biomedicinal(vaccines, chemotherapeutics) projects capable of providing results with potential applications at the practical level. By solving the above scientific tasks, the team will increase its international competitiveness. At the same time, the project will
Publications
Total number of publications: 284
2011
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QM/MM Studies of Hairpin Ribozyme Self-Cleavage Suggest the Feasibility of Multiple Competing Reaction Mechanisms
JOURNAL OF PHYSICAL CHEMISTRY B, year: 2011, volume: 115, edition: 47, DOI
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QSPR modeling – algorithms, challenges and IT solutions
Year: 2011, type: Conference abstract
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Random mutagenesis of lectins and high-throughput screening of mutant libraries
Year: 2011, type: Conference abstract
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Reaction Mechanism of MutH Enzyme - Quantum Mechanics/Molecular Mechanics Study 2
Year: 2011, type: Conference abstract
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Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities
DNA Repair, year: 2011, volume: 10, edition: 6, DOI
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Structure and specificity of a blood group oligosaccharide specific lectin from Aspergillus fumigatus
Year: 2011, type: Conference abstract
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Study of RNA polymerase delta subunit unique for gram-positive bacteria
Year: 2011, type: Conference abstract
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STUDY OF THE CARBOHYDRATE CH/pi INTERACTIONS FAVOURABLE REGIONS IN THE CARBOHYDRATE SURROUNDINGS
Year: 2011, type: Conference abstract
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Systematic Study of Carbohydrate-Aromatic CH-pi Dispersion Interaction by DFT and Highly Correlated Ab Initio Methods
Year: 2011, type: Conference abstract
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THEORETICAL INVESTIGATION OF THE CARBOHYDRATE CH/pi INTERACTIONS FAVOURABLE REGIONS IN THE CARBOHYDRATE SURROUNDINGS
Year: 2011, type: Conference abstract