Project information
Molecular pathophysiology of multigene diseases
- Project Identification
- MSM 141100002
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- Multigenic disease, essential hypertension, ischemia, atopy, diabetes type II, late complications of diabetes, matrix metalloproteinase, gene polymorphism, remodeling, gene derepression, case-control study, PCR, SSCP, RFLP, sequencing.
Effects of allelic variability of the genes coding for matrix metalloproteinases (MMPs) on the etiopathogenesis of the essential hypertension, myocardial ischemia, atopic diseases, and late complications of diabetes II will be studied. Genotyping of individuals will be performed using molecular biological methods, especially PCR, SSCP, RFLP, and/or direct sequencing. Groups of diseased persons will be compared with the appropriate control groups (case-control study).
Publications
Total number of publications: 233
2000
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Apolipoprotein B signal peptide polymorphism in relation to lipids and diabetes in male CAD patients
Atherosclerosis, year: 2000, volume: 152, edition: 1
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Asociace psoriázy se dvěma genetickými polymorfismy v genu pro angiotenzinogen.
Česko-slovenská dermatologie, year: 2000, volume: 75, edition: 4
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Cost-effectivness of factor V Leiden screening among oral contraceptive users
Contraceptive Choices and Ralities, year: 2000
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Factor V Leiden in Patients with recurrent Fetal Loss
Book of Abstracts of XVI. FIGO World Congress, year: 2000
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Functional polymorphism in the gelationase B gene and asthma
Allergy, year: 2000, volume: 55, edition: 9
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Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study
Homeostasis, year: 2000, volume: 40, edition: 3-4
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Genital Chlamidia trachomatis infections in the Czech Republic
Chlamidia trachomatis infections in Eastern Europe, year: 2000
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Identification of novel common polymorphisms in the promoter region of the TIMP-3 gene in Czech population
Molecular and Cellular Probes, year: 2000, volume: 4, edition: 14
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Immunohistochemical characterisation and PEPSCAN ANALYSIS of monoclonal antibodies against D-type Cyclin-dependent kinase Cdk6
Cells II, year: 2000
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Interakce mutace M235T genu pro angiotenzinogen a mutace Taq1 8000 v genu pro endotelin-1 při vzniku esenciální hypertenze
Časopis lékařů českých, year: 2000, volume: 2000, edition: 15