Factor V Leiden in Patients with recurrent Fetal Loss
| Authors | |
|---|---|
| Year of publication | 2000 |
| Type | Article in Proceedings |
| Conference | Book of Abstracts of XVI. FIGO World Congress |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Factor V Leiden; fetal loss |
| Description | S u m m a r y: The factor V Leiden mutation is the most common genetic predisposition to thrombosis. Our purpose was to determine the association of Factor V Leiden mutation (FVL) frequency and recurrent fetal loss.We examined the prevalence of the point mutation in the factor V gene (R 506 Q or Leiden) in 138 unselected women with a history of one or more spontaneous abortion or stillbirth of unexplained etiology. In our referral population women, a statistically significant association of the Leiden mutation with recurrent fetal losses was found. The risk for recurrence of fetal loss tended to be greater in homozygous carriers. |
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